Why does that matter? Because better understanding the physiology of gratitude can help pinpoint strategies for harnessing its health benefits and help people understand the importance of fostering this powerful emotion. The goal of my research has been to lay the groundwork for understanding what happens in the brain when we feel grateful—and a picture of the grateful brain is now starting to emerge. When I first embarked on the journey to study gratitude, I came across philosophical treatises and religious exhortations emphasizing the importance of gratitude, along with scientific studies suggesting that gratitude can improve your sleep, enhance your romantic relationships, protect you from illness, motivate you to exercise, and boost your happiness, among many other benefits. At the time, however, very little was known about what happens in our brains and bodies when we experience gratitude, which made it difficult to understand how gratitude actually works. Since I’m a neuroscientist, I zeroed in on the neurobiology of gratitude with a more specific question in mind: Can our brain activity reveal anything about how gratitude achieves its significant benefits?

How Gratitude Strengthens the Mind-Body Connection

Given the clear relationship between mental and physical health, I thought that understanding what happens in the brain when we feel gratitude could tell us more about the mind-body connection—namely, how feeling positive emotion can improve bodily functions. I also thought these results could help scientists design programs aimed at generating gratitude by helping them zero in on the precise activities and experiences most essential to reaping gratitude’s benefits. It must be said that actually capturing people in the moment of feeling gratitude poses some challenges. After all, some people may not feel gratitude when we expect them to, and others may even feel grateful in unexpected situations. I thought my best bet would be to try to induce gratitude through powerful stories of aid and sacrifice. To achieve this, I turned to the USC Shoah Foundation Institute for Visual History, which houses the world’s largest repository of videotaped Holocaust survivor testimonies—many of which, perhaps surprisingly, are filled with breathtaking acts of selflessness and generosity. Along with a team of amazing undergraduates, I began by watching hundreds of hours of survivor testimony to find stories in which the survivor received help of some kind from another person. We assembled a collection of these stories and transformed them into short scenarios that we shared with our participants. Each scenario was re-phrased into the second-person (e.g., “You are on a wintertime death march and a fellow prisoner gives you a warm coat”) and presented to our study’s participants. We asked them to imagine themselves in the scenario and feel, as much as possible, how they would feel if they were in the same situation. While participants reflected on these gifts, we measured their brain activity using modern brain imaging techniques (in the form of functional magnetic resonance imaging, or fMRI). For each of these scenarios, we asked participants how much gratitude they felt, and we correlated this rating with their brain activity in that moment. While such an approach will not elicit exactly the same feelings as actually living through such situations, participants overwhelmingly reported strong feelings of gratitude, deep engagement in the task, and, perhaps even more importantly, an increased empathy for and understanding of the Holocaust as a result of participating in the study. What’s more, our results revealed that when participants reported those grateful feelings, their brains showed activity in a set of regions located in the medial pre-frontal cortex, an area in the frontal lobes of the brain where the two hemispheres meet. This area of the brain is associated with understanding other people’s perspectives, empathy, and feelings of relief. This is also an area of the brain that is massively connected to the systems in the body and brain that regulate emotion and support the process of stress relief.

Three Ways Gratitude Benefits Our Minds

These data told us a reasonable story about gratitude:

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Mindful Staff September 21, 2022

Stephanie Domet November 13, 2018

Elaine Smookler April 26, 2018